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Karunesh Arora and Charles L. Brooks III, Functionally important conformations of the Met20 loop in dihydrofolate reductase are populated by rapid thermal fluctuations, J. Am. Chem. Soc. 131 (2009) 5642-5647. 確かに Transition state theory のプレファクターで４ケタも変えようというセンスがよく分からん。